Getting Started
ULTOMIRIS® offers predictable maintenance dosing once every 8 weeks
ULTOMIRIS (ravulizumab-cwvz) is delivered through a vein by intravenous infusion just 6-7 times per year after your initial dose. While travel and wait times may vary, infusions take less than 1 hour for most people*

ULTOMIRIS dosing schedule
The recommended dosing regimen starts with an initial dose. 2 weeks afterward, you can begin maintenance dosing once every 8 weeks.
- After your infusion, your care team will monitor you for at least an additional hour for infusion-related reactions
*Minimum infusion times for ULTOMIRIS 100 mg/mL maintenance doses range from 30 minutes to less than 1 hour, depending on body weight. If a side effect occurs during the infusion of ULTOMIRIS, the infusion may be slowed or stopped by the healthcare provider.
Find an infusion location near you
ULTOMIRIS is administered at an infusion location or doctor's office by a healthcare professional. Ask your doctor about their office's infusion capabilities, or use the search tool below to find an infusion location that's convenient for you.
Vaccination requirements
If you have not already had them, you must receive the meningococcal vaccines at least 2 weeks before your first dose of ULTOMIRIS
ULTOMIRIS can lower the ability of your immune system to fight some infections. Before taking ULTOMIRIS, you must be vaccinated against meningococcal infection, a severe and life-threatening infection that can occur in the blood and that requires immediate medical attention. Your healthcare provider or nurse will make sure you receive these vaccines at least 2 weeks before your first infusion.

If your healthcare provider decides that urgent treatment with ULTOMIRIS is needed, you should get the meningococcal vaccines as soon as possible. If you have not been vaccinated and ULTOMIRIS must be started immediately, you should also receive antibiotics until 2 weeks after vaccination.
If you had a meningococcal vaccine in the past, you might need a booster dose before starting ULTOMIRIS. Your healthcare provider will decide if you need a booster dose for meningococcal infections.
Vaccination reduces, but does not eliminate, the risk of meningococcal infections. Call your healthcare provider or get emergency medical care right away if you get any of these signs and symptoms of a meningococcal infection:
- headache with nausea or vomiting
- headache and fever
- headache with a stiff neck or stiff back
- fever
- fever and a rash
- confusion
- muscle aches with flu-like symptoms
- eyes sensitive to light
Carry your Patient Safety Card

Your healthcare provider will give you a Patient Safety Card about the risk of meningococcal infection.
Carry it with you at all times during treatment and for 8 months after your last ULTOMIRIS dose. Your risk of meningococcal infection may continue for several months after your last dose of ULTOMIRIS.
It is important to show this card to any healthcare provider or nurse who treats you. This will help them diagnose and treat you quickly.
ULTOMIRIS REMS
ULTOMIRIS is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS)
Before you can receive ULTOMIRIS, your healthcare provider must:
- enroll in the ULTOMIRIS REMS program
- counsel you about the risk of meningococcal infection
- give you information about the symptoms of meningococcal infection
With only 6-7 maintenance infusions per year, ULTOMIRIS dosing leaves you with more time to do what you love